查看“KRAS G12”的源代码

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        <span>🧬 KRAS G12 核心临床数据摘要</span>
        <span style="font-size: 0.8em; color: #64748b;">[点击查看详情]</span>
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                <div style="font-size: 0.85em; color: #94a3b8; margin-top: 10px;">KRAS G12 结构枢纽图</div>
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                <th style="padding: 10px; color: #64748b;">突变位点</th>
                <td style="padding: 10px; font-weight: 600;">12 号密码子 (P-loop)</td>
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                <th style="padding: 10px; color: #64748b;">优势癌种</th>
                <td style="padding: 10px;">胰腺癌、结直肠癌、NSCLC</td>
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                <th style="padding: 10px; color: #64748b;">成药性</th>
                <td style="padding: 10px; color: #059669;">部分成药 (G12C 抑制剂已上市)</td>
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'''KRAS G12''' 突变簇是肿瘤精准诊疗中最重要的生物标志物之一。由于该位点紧邻 GTP 结合口袋，其突变会直接导致蛋白质锁死在激活状态，驱动下游信号通路的持续震荡。

== 信号传导通路 ==
突变后的 KRAS 蛋白通过以下路径诱发细胞恶性转化：

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    <span style="font-family: 'Times New Roman', serif; font-size: 1.2em; font-weight: bold; color: #b91c1c;">KRAS-G12 (Active)</span>
    <span style="margin: 0 12px; color: #3b82f6; font-size: 1.3em;">→</span>
    <span style="font-family: 'Times New Roman', serif; font-size: 1.15em; font-style: italic;">RAF / MEK / ERK</span>
    <span style="margin: 0 8px; color: #94a3b8;">&</span>
    <span style="font-family: 'Times New Roman', serif; font-size: 1.15em; font-style: italic;">PI3K / AKT</span>
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== 亚型临床分布 ==
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|+ KRAS G12 主要突变亚型频率
|-
! style="background: #f1f5f9;" | 亚型 !! 胰腺癌 !! 结直肠癌 !! 肺腺癌
|-
| '''G12D''' || 41% || 12% || 4%
|-
| '''G12V''' || 30% || 22% || 15%
|-
| '''G12C''' || 1% || 7% || 14%
|}
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== 参考文献 ==
{{reflist}}

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'''相关词条：''' [[KRAS G12C]] • [[KRAS G12D]] • [[KRAS G12V]] • [[靶向治疗]] • [[SinoCellGene]]
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[[Category:人类基因]]
[[Category:KRAS突变体]]