查看“胰腺癌”的源代码

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                    胰腺癌示意图
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            <p style="font-size: 12px; color: #64748b; margin-top: 12px; font-weight: 500;">Pancreatic Adenocarcinoma</p>
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        <table style="width: 100%; font-size: 13px; border-collapse: collapse;">
            <tr style="border-bottom: 1px solid #f1f5f9;">
                <td style="padding: 10px 15px; color: #64748b; font-weight: bold; width: 90px;">中文名称</td>
                <td style="padding: 10px 15px; color: #1e293b;">胰腺癌</td>
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            <tr style="border-bottom: 1px solid #f1f5f9;">
                <td style="padding: 10px 15px; color: #64748b; font-weight: bold;">英文名称</td>
                <td style="padding: 10px 15px; color: #1e293b; font-style: italic;">Pancreatic Cancer</td>
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            <tr style="border-bottom: 1px solid #f1f5f9;">
                <td style="padding: 10px 15px; color: #64748b; font-weight: bold;">常见类型</td>
                <td style="padding: 10px 15px; color: #1e293b;">导管腺癌 (PDAC)</td>
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            <tr style="border-bottom: 1px solid #f1f5f9;">
                <td style="padding: 10px 15px; color: #64748b; font-weight: bold;">ICD-10</td>
                <td style="padding: 10px 15px; color: #1e293b;">C25</td>
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            <tr>
                <td style="padding: 10px 15px; color: #64748b; font-weight: bold;">主要标志物</td>
                <td style="padding: 10px 15px; color: #1e293b;">CA19-9, CEA</td>
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    <h1 style="font-size: 2.2em; color: #2d3748; margin-bottom: 15px; border-bottom: 3px solid #3182ce; padding-bottom: 10px;">胰腺癌</h1>
    
    <p style="text-indent: 2em; margin-bottom: 1.5em;">
        <b>胰腺癌</b>（Pancreatic Cancer）是消化道常见的极具侵袭性的恶性肿瘤。由于其早期诊断极难、手术切除率低、对传统放化疗不敏感，且预后在所有实体瘤中最为严峻，故临床上常被称为<b>“癌中之王”</b>。超过90%的病例为发生于胰腺外分泌腺的<b>导管腺癌（PDAC）</b>。
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    <h2 style="font-size: 1.6em; color: #2b6cb0; border-left: 6px solid #3182ce; padding-left: 15px; margin-top: 40px; margin-bottom: 20px;">分期与临床特征</h2>
    
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            <thead>
                <tr style="background-color: #edf2f7; color: #2d3748;">
                    <th style="padding: 12px; border: 1px solid #e2e8f0; width: 25%;">分期</th>
                    <th style="padding: 12px; border: 1px solid #e2e8f0;">解剖学范围 (TNM简化)</th>
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            <tbody>
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                    <td style="padding: 10px; border: 1px solid #e2e8f0; font-weight: 500;">I 期 (早期)</td>
                    <td style="padding: 10px; border: 1px solid #e2e8f0;">肿瘤局限于胰腺内部，无淋巴结转移。</td>
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                    <td style="padding: 10px; border: 1px solid #e2e8f0; background: #f8fafc; font-weight: 500;">II 期 (局部)</td>
                    <td style="padding: 10px; border: 1px solid #e2e8f0; background: #f8fafc;">侵犯邻近组织（十二指肠/胆管）或1-3个淋巴结受累。</td>
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                    <td style="padding: 10px; border: 1px solid #e2e8f0; font-weight: 500;">III 期 (局部晚期)</td>
                    <td style="padding: 10px; border: 1px solid #e2e8f0;">侵犯腹腔干或肠系膜上动脉等大血管。</td>
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                    <td style="padding: 10px; border: 1px solid #e2e8f0; background: #fff5f5; color: #c53030; font-weight: bold;">IV 期 (转移)</td>
                    <td style="padding: 10px; border: 1px solid #e2e8f0; background: #fff5f5;">远处转移，多见于肝、肺、腹膜。</td>
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    <h2 style="font-size: 1.6em; color: #2b6cb0; border-left: 6px solid #3182ce; padding-left: 15px; margin-top: 40px;">诊疗关键路径</h2>
    
    <h3 style="color: #4a5568; margin-top: 20px;">1. 精准诊断</h3>
    <ul>
        <li><b>影像学金标准：</b>胰腺协议增强CT、MRI/MRCP。</li>
        <li><b>病理确诊：</b>超声内镜引导下的细针穿刺（EUS-FNA）。</li>
        <li><b>肿瘤标志物：</b>CA19-9（用于疗效监测而非单一筛查）。</li>
    </ul>

    <h3 style="color: #4a5568; margin-top: 20px;">2. 综合治疗与前沿研究</h3>
    <p style="margin-bottom: 10px;">
        胰腺癌的治疗已从单一手术转变为<b>多学科协作（MDT）</b>模式：
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    <ul>
        <li><b>新辅助治疗：</b>针对交界可切除患者，术前进行化疗（FOLFIRINOX）以缩小肿瘤。</li>
        <li><b>分子靶向：</b>针对 <i>KRAS G12C/D</i>、<i>BRCA1/2</i> 突变的精准靶向策略。</li>
        <li><b>细胞与免疫治疗：</b>针对胰腺癌高纤维化微环境的突破，如 <b>CAR-T 细胞疗法</b>（针对 MSLN, CEA 抗原）及 <b>TILs 疗法</b> 正处于活跃临床试验阶段。</li>
    </ul>

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            <b>注：</b> 胰腺癌早期症状常表现为非特异性腹痛、体重减轻或新发糖尿病。40岁以上人群如出现不明原因上述体征，建议及时进行血清 CA19-9 及影像学筛查。
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