查看“NKT细胞”的源代码

<div style="padding: 0 2%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff;">

<div style="margin-bottom: 25px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 20px;">
    <p style="font-size: 1.15em; margin: 10px 0; color: #0f172a; font-weight: 500;">
        <strong>NKT细胞</strong>（Natural Killer T Cell）系一类兼具 T 淋巴细胞（表达 [[TCR]]）与 NK 细胞（表达 CD56/CD161）表面标志物的独特免疫细胞亚群。其核心特征在于识别由非多态性 **[[CD1d]]** 分子呈递的脂质或糖脂抗原，而非传统的 MHC 限制性肽抗原。作为免疫系统的“轴心调节者”，NKT 细胞在抗肿瘤免疫、自身免疫疾病及感染性疾病的病理生理过程中发挥着关键的跨系统协同作用。
    </p>
</div>

<div class="medical-infobox mw-collapsible mw-collapsed" style="float: right; width: 320px; margin: 0 0 25px 25px; border: 1.5px solid #94a3b8; border-radius: 12px; background-color: #ffffff; box-shadow: 0 10px 25px rgba(0,0,0,0.08); overflow: hidden;">
    
    <div style="padding: 18px 15px; color: #ffffff; background: linear-gradient(135deg, #0f172a 0%, #1e40af 100%); text-align: center; cursor: pointer;">
        <div style="font-size: 1.25em; font-weight: bold; letter-spacing: 1.5px;">NKT细胞 · 生物图谱</div>
        <div style="font-size: 0.75em; opacity: 0.9; margin-top: 5px; white-space: nowrap;">NKT Cell Biological Atlas (点击展开)</div>
    </div>
    
    <div class="mw-collapsible-content">
        <div style="padding: 30px; text-align: center; background-color: #f8fafc;">
            <div style="display: inline-block; background: #ffffff; border: 1px solid #cbd5e1; border-radius: 8px; padding: 25px; box-shadow: 0 4px 6px rgba(0,0,0,0.05);">
                
            </div>
            <div style="font-size: 0.85em; color: #475569; margin-top: 15px; font-weight: 600;">TCR 与 CD1d-糖脂复合物之交互视阈</div>
        </div>

        <table style="width: 100%; border-spacing: 0; border-collapse: collapse; font-size: 0.9em;">
            <tr>
                <th style="text-align: left; padding: 12px 18px; border-bottom: 1px solid #f1f5f9; color: #475569; font-weight: 600; width: 40%; background-color: #f8fafc;">限制性分子</th>
                <td style="padding: 12px 18px; border-bottom: 1px solid #f1f5f9; color: #0f172a;">[[CD1d]]</td>
            </tr>
            <tr>
                <th style="text-align: left; padding: 12px 18px; border-bottom: 1px solid #f1f5f9; color: #475569; font-weight: 600; background-color: #f8fafc;">经典配体</th>
                <td style="padding: 12px 18px; border-bottom: 1px solid #f1f5f9; color: #0f172a;">$\alpha$-GalCer</td>
            </tr>
            <tr>
                <th style="text-align: left; padding: 12px 18px; color: #475569; font-weight: 600; background-color: #f8fafc;">免疫定位</th>
                <td style="padding: 12px 18px; color: #1e40af; font-weight: bold;">先天-适应性桥梁</td>
            </tr>
        </table>
    </div>
</div>

<h2 style="background: linear-gradient(to right, #0f172a, #3b82f6); color: #ffffff; padding: 10px 18px; border-radius: 4px; font-size: 1.25em; margin-top: 35px; border-left: 6px solid #1e3a8a;">生物学机制：从糖脂识别到系统动员</h2>
<p style="margin: 15px 0;">
    NKT 细胞（主要指 I 型不变型 NKT，iNKT）通过其半恒定（Semi-invariant）的 [[TCR]] 链实现对抗原的高效扫描：
</p>
<ul style="padding-left: 20px; color: #334155;">
    <li style="margin-bottom: 12px;"><strong>CD1d 限制性识别：</strong> 不同于识别 MHC 肽段的传统 T 细胞，NKT 识别的是由非多态性 CD1d 分子提呈的[[糖脂]]抗原。</li>
    <li style="margin-bottom: 12px;"><strong>爆发式细胞因子分泌：</strong> 激活后能迅速分泌大量 [[IFN-γ]]（Th1 型）及 IL-4（Th2 型），产生瀑布式免疫应答。</li>
    <li style="margin-bottom: 12px;"><strong>直接细胞毒性：</strong> 通过[[穿孔素]]与[[颗粒酶]]路径，诱导肿瘤细胞凋亡。</li>
</ul>

<h2 style="background: linear-gradient(to right, #0f172a, #3b82f6); color: #ffffff; padding: 10px 18px; border-radius: 4px; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #1e3a8a;">NKT 细胞与传统免疫细胞对比</h2>
<div style="overflow-x: auto; margin: 30px 0;">
    <table style="width: 85%; max-width: 600px; border-collapse: collapse; border: 1px solid #cbd5e1; font-size: 0.95em; text-align: left;">
        <tr style="background-color: #f1f5f9; border-bottom: 2.5px solid #0f172a;">
            <th style="padding: 12px; border: 1px solid #cbd5e1;">特性</th>
            <th style="padding: 12px; border: 1px solid #cbd5e1;">[[CD8+ T细胞]]</th>
            <th style="padding: 12px; border: 1px solid #cbd5e1;">NKT 细胞</th>
        </tr>
        <tr>
            <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: bold;">识别分子</td>
            <td style="padding: 10px; border: 1px solid #cbd5e1;">MHC-I</td>
            <td style="padding: 10px; border: 1px solid #cbd5e1; color: #16a34a; font-weight: bold;">CD1d</td>
        </tr>
        <tr>
            <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: bold;">抗原类型</td>
            <td style="padding: 10px; border: 1px solid #cbd5e1;">肽类</td>
            <td style="padding: 10px; border: 1px solid #cbd5e1; color: #16a34a; font-weight: bold;">脂类/糖脂</td>
        </tr>
        <tr>
            <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: bold;">反应速度</td>
            <td style="padding: 10px; border: 1px solid #cbd5e1;">数日</td>
            <td style="padding: 10px; border: 1px solid #cbd5e1; color: #16a34a; font-weight: bold;">数小时</td>
        </tr>
    </table>
</div>

<h2 style="background: linear-gradient(to right, #0f172a, #3b82f6); color: #ffffff; padding: 10px 18px; border-radius: 4px; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #1e3a8a;">参考文献</h2>
<div style="font-size: 0.9em; line-height: 1.6; color: #1e293b; margin-top: 15px; background-color: #f8fafc; padding: 20px; border-radius: 8px; border-top: 3px solid #0f172a;">
    <p style="margin: 10px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;">
        [1] <strong>Godfrey D I, et al. (2018).</strong> <em>The biology and functional diversity of NKT cells.</em> <strong>Nature Reviews Immunology</strong>. <br>
        <span style="color: #1e40af; font-weight: 500;">[学术点评]：该综述系统界定了 iNKT 在肿瘤监测中的枢纽作用，是研究先天-适应性免疫交汇点的纲领性文献。</span>
    </p>
    <p style="margin: 10px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;">
        [2] <strong>Brennan P J, et al. (2013).</strong> <em>Invariant natural killer T cells: an innate activation scheme based on self-lipid recognition.</em> <strong>Nature Reviews Immunology</strong>. <br>
        <span style="color: #1e40af; font-weight: 500;">[学术点评]：详述了 NKT 细胞识别内源性脂质抗原的分子机制，阐明了其在维持机体稳态中的基础地位。</span>
    </p>
    <p style="margin: 10px 0;">
        [3] <strong>Van Kaer L, et al. (2013).</strong> <em>NKT cells as targets for immunotherapy.</em> <strong>Expert Opinion on Therapeutic Targets</strong>. <br>
        <span style="color: #1e40af; font-weight: 500;">[学术点评]：深入探讨了利用脂质配体激活 NKT 以调节全局免疫应答的转化医学策略，为后续 CAR-NKT 研发提供了理论支持。</span>
    </p>
</div>

<div style="margin: 45px 0; border: 1.5px solid #0f172a; border-radius: 8px; overflow: hidden; font-size: 0.95em;">
    <div style="background-color: #0f172a; color: #ffffff; text-align: center; font-weight: bold; padding: 12px; letter-spacing: 2px;">相关知识导航</div>
    <div style="padding: 20px; background: #ffffff; line-height: 2.2; text-align: center;">
        [[CD1d限制性识别]] • [[CAR-NKT]] • [[alpha-GalCer]] • [[通用型细胞治疗]] • [[肿瘤浸润淋巴细胞]]
    </div>
</div>

</div>