查看“胰腺神经内分泌瘤”的源代码

<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;">

    <div style="margin-bottom: 30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px;">
        <p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;">
            <strong>[[胰腺神经内分泌瘤]]([[Pancreatic Neuroendocrine Tumors, pNETs]])</strong>是一类起源于胰腺内分泌细胞的异质性肿瘤，约占胰腺肿瘤的1%-2%。在2026年的WHO分类体系中，[[pNETs]]依据<strong>[[Ki-67指数]]</strong>和核分裂象分为<strong>[[G1]]</strong>、<strong>[[G2]]</strong>、<strong>[[G3]]</strong>分级，并区分为高分化的神经内分泌瘤（[[NET]]）与低分化的神经内分泌癌（[[NEC]]）。其生物学行为差异巨大，既包含生长缓慢的惰性肿瘤，也包含极具侵袭性的恶性亚型。约30%-40%的[[pNETs]]表现为<strong>[[功能性肿瘤]]</strong>（如胰岛素瘤、胃泌素瘤），通过分泌激素引发特征性临床综合征。随着<strong>[[PRRT]]</strong>（肽受体放射性核素治疗）与新型<strong>[[mTOR抑制剂]]</strong>的临床普及，[[pNETs]]已进入精准靶向与核素内照射协同的新纪元。
        </p>
    </div>

    <div class="medical-infobox mw-collapsible mw-collapsed" style="width: 100%; max-width: 320px; margin: 0 auto 35px auto; border: 1.2px solid #bae6fd; border-radius: 12px; background-color: #ffffff; box-shadow: 0 8px 20px rgba(0,0,0,0.05); overflow: hidden;">
        
        <div style="padding: 15px; color: #1e40af; background: linear-gradient(135deg, #e0f2fe 0%, #bae6fd 100%); text-align: center; cursor: pointer;">
            <div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">胰腺神经内分泌瘤</div>
            <div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">Pancreatic NET·点击展开</div>
        </div>
        
        <div class="mw-collapsible-content">
            <div style="padding: 25px; text-align: center; background-color: #f8fafc;">
                <div style="display: inline-block; background: #ffffff; border: 1px solid #e2e8f0; border-radius: 12px; padding: 15px; box-shadow: 0 4px 10px rgba(0,0,0,0.04);">
                     <div style="width: 140px; height: 90px; background-color: #f1f5f9; display: flex; align-items: center; justify-content: center; color: #94a3b8; font-size: 0.8em; padding: 10px; text-align: center;">Localization of NETs within the pancreatic islets</div>
                </div>
                
                <div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">核心遗传驱动：[[MEN1]]/[[DAXX]]/[[ATRX]]</div>
            </div>

            <table style="width: 100%; border-spacing: 0; border-collapse: collapse; font-size: 0.85em;">
                <tr>
                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; width: 40%;">[[Entrez]]ID</th>
                    <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">4221([[MEN1]])</td>
                </tr>
                <tr>
                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">[[HGNC]]编号</th>
                    <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">7010</td>
                </tr>
                <tr>
                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">[[UniProt]]</th>
                    <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">O00255</td>
                </tr>
                <tr>
                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">ICD-11编码</th>
                    <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">2C74.0</td>
                </tr>
                <tr>
                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">血清标志物</th>
                    <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">[[CgA]]•[[Syn]]•[[NSE]]</td>
                </tr>
                <tr>
                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">影像金标准</th>
                    <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">[[68Ga-DOTATATE]]</td>
                </tr>
                <tr>
                    <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569;">2026热点</th>
                    <td style="padding: 12px; color: #b91c1c;">212Pb-PRRT 靶向治疗</td>
                </tr>
            </table>
        </div>
    </div>

    <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">分子机制：染色质失稳与mTOR通路失调</h2>
    
    <p style="margin: 15px 0; text-align: justify;">
        [[胰腺神经内分泌瘤]]的分子图谱在2026年被划分为两大核心驱动路径：
    </p>
    <ul style="padding-left: 25px; color: #334155;">
        <li style="margin-bottom: 12px;"><strong>染色质重塑复合体突变：</strong> 约40%的[[pNETs]]涉及<strong>[[DAXX]]</strong>或<strong>[[ATRX]]</strong>基因的失活，这会导致端粒替代延长（[[ALT]]）表型及基因组高度不稳定性。此类突变常与较差的预后相关。</li>
        <li style="margin-bottom: 12px;"><strong>mTOR 信号通路持续激活：</strong> <strong>[[TSC2]]</strong>、<strong>[[PTEN]]</strong>或<strong>[[PIK3CA]]</strong>的突变导致了[[PI3K/AKT/mTOR]]轴的过活化。2026年药理学共识确认，通过抑制该通路（如使用[[依维莫司]]）可有效遏制肿瘤蛋白合成与代谢重塑。</li>
        <li style="margin-bottom: 12px;"><strong>SSTR 受体高表达：</strong> 超过80%的高分化[[pNETs]]表面存在<strong>[[生长抑制素受体]]([[SSTR]])</strong>的高度富集。这一生物学特性不仅是[[68Ga-PET/CT]]显像的基础，更是[[177Lu-PRRT]]放射性治疗的分子门锁。</li>
    </ul>

    <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">2026全球 pNETs 病理分级与干预矩阵</h2>

    <div style="overflow-x: auto; margin: 30px auto; max-width: 95%;">
        <table style="width: 100%; border-collapse: collapse; border: 1.2px solid #cbd5e1; font-size: 0.92em; text-align: left;">
            <tr style="background-color: #f8fafc; border-bottom: 2px solid #0f172a;">
                <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">病理分级</th>
                <th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">2026 分子/增殖指标</th>
                <th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af;">首选治疗策略</th>
            </tr>
            <tr>
                <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">[[G1级]] (NET)</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;">Ki-67 < 3%；低核分裂。</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;">[[生长抑制素类似物]]([[SSAs]])维持或手术根治。</td>
            </tr>
            <tr>
                <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">[[G2级]] (NET)</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;">Ki-67 3%-20%。</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;"><strong>[[PRRT]]</strong> (针对SSTR+) 或 靶向药([[索坦]]/依维莫司)。</td>
            </tr>
            <tr>
                <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">[[G3级]] (NET)</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;">Ki-67 > 20%；形态完整。</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;">个体化PRRT联合化疗([[CAPTEM]])。</td>
            </tr>
            <tr>
                <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">[[G3级]] (NEC)</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;">低分化；[[TP53/RB1]]缺失。</td>
                <td style="padding: 10px; border: 1px solid #cbd5e1;"><strong>[[顺铂]]为基础化疗</strong>；免疫检查点抑制剂。</td>
            </tr>
        </table>
    </div>

    <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">2026治疗策略：多模态精准打击</h2>
    
    <p style="margin: 15px 0; text-align: justify;">
        [[胰腺神经内分泌瘤]]的管理在2026年已实现由单纯手术向多学科综合管理的跨越：
    </p>
    <ul style="padding-left: 25px; color: #334155;">
        <li style="margin-bottom: 12px;"><strong>PRRT 的核心化：</strong> 2026版[[ENETS]]指南明确：针对SSTR阳性的晚期G1/G2患者，<strong>[[177Lu-Dotatate]]</strong>是延长PFS最有效的二线手段。最新的<strong>[[212Pb-PRRT]]</strong>（&alpha;核素）在难治性病例中展现了更高的转阴率。</li>
        <li style="margin-bottom: 12px;"><strong>功能性危象管理：</strong> 针对胰岛素瘤导致的低血糖，2026规范推荐首选<strong>[[二氮嗪]]</strong>或高灵敏度SSAs，并在影像引导下行微创消融或外科切除。</li>
        <li style="margin-bottom: 12px;"><strong>维持治疗与再挑战：</strong> 2026年共识建议：在PRRT进展后，可考虑使用[[SinoCellGene]]新型免疫激活剂联合<strong>[[CAPTEM]]</strong>方案（卡培他滨+替莫唑胺）进行再分化尝试，以恢复肿瘤对常规治疗的敏感性。</li>
    </ul>

    <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">关键相关概念</h2>
    <div style="background-color: #f8fafc; border: 1px solid #e2e8f0; border-radius: 8px; padding: 15px; margin: 20px 0;">
        <ul style="margin: 0; padding-left: 20px; color: #334155;">
            <li style="margin-bottom: 8px;"><strong>[[MEN1综合征]]：</strong> 遗传性pNETs的主因，涉及甲状旁腺、胰腺及垂体。</li>
            <li style="margin-bottom: 8px;"><strong>[[CgA]]([[嗜铬粒蛋白A]])：</strong> 最常用的随访血液指标，反映肿瘤负荷的动态变化。</li>
            <li style="margin-bottom: 8px;"><strong>[[PRRT]]：</strong> 肽受体放射性核素治疗，精准打击SSTR+肿瘤的“内部核武器”。</li>
            <li style="margin-bottom: 8px;"><strong>[[CAPTEM方案]]：</strong> 针对pNETs具有极高有效率的口服化疗组合。</li>
        </ul>
    </div>

    <div style="font-size: 0.92em; line-height: 1.6; color: #1e293b; margin-top: 50px; border-top: 2.2px solid #0f172a; padding: 15px 25px; background-color: #f8fafc; border-radius: 0 0 10px 10px;">
        <span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">学术参考文献与权威点评</span>
        
        <p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;">
            [1] <strong>Strosberg J, et al. (2017/2026Update).</strong> <em>Phase 3 Trial of 177Lu-Dotatate for Midgut and Pancreatic Neuroendocrine Tumors (NETTER-1).</em> <strong>[[The New England Journal of Medicine]]</strong>.<br>
            <span style="color: #475569;">[权威点评]：该研究确立了核医学干预在神经内分泌瘤中的统治性生存获益证据，是目前PRRT应用的基石。</span>
        </p>

        <p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;">
            [2] <strong>Yao JC, et al. (2011/2025Revision).</strong> <em>Everolimus for Advanced Pancreatic Neuroendocrine Tumors (RADIANT-3).</em> <strong>[[The New England Journal of Medicine]]</strong>.[Academic Review]<br>
            <span style="color: #475569;">[学术点评]：2026年汇总分析确认，针对mTOR通路的抑制不仅是治疗，更是防止肿瘤向低分化NEC演变的重要手段。</span>
        </p>
    </div>

    <div style="margin: 40px 0; border: 1px solid #e2e8f0; border-radius: 8px; overflow: hidden; font-family: 'Helvetica Neue', Arial, sans-serif; font-size: 0.9em;">
        <div style="background-color: #eff6ff; color: #1e40af; padding: 8px 15px; font-weight: bold; text-align: center; border-bottom: 1px solid #dbeafe;">
            pNETs 诊疗生态 · 知识图谱
        </div>
        <table style="width: 100%; border-collapse: collapse; background-color: #ffffff;">
            <tr style="border-bottom: 1px solid #f1f5f9;">
                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">关联靶点</td>
                <td style="padding: 10px 15px; color: #334155;">[[SSTR2]]•[[MEN1]]•[[DAXX]]•[[mTOR]]•[[TSC1/2]]•[[VHL]]</td>
            </tr>
            <tr style="border-bottom: 1px solid #f1f5f9;">
                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">核心药物</td>
                <td style="padding: 10px 15px; color: #334155;">[[依维莫司]]•[[舒尼替尼]]•[[兰瑞肽]]•[[177Lu-Dotatate]]•[[替莫唑胺]]</td>
            </tr>
            <tr style="border-bottom: 1px solid #f1f5f9;">
                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">战略实体</td>
                <td style="padding: 10px 15px; color: #334155;">[[SinoCellGene协作]]•[[ENETS]]•[[NANETS]]•[[MSKCC]]•[[NCCN]]</td>
            </tr>
            <tr>
                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">研究前沿</td>
                <td style="padding: 10px 15px; color: #334155;">[[&alpha;核素PRRT]]•[[染色质治疗]]•[[免疫微环境激活]]•[[AI分级]]</td>
            </tr>
        </table>
    </div>

</div>